What You Should Know About Nicotinamide Riboside: NIAGEN




Niagen
 is a new breakthrough formula, developed to include a bioavailable form of Vitamin B3, also known as Nicotinamide Riboside. The formula includes vitamin B3 as well as a valuable precursor to an anti-aging compound known as NAD+. Now available through the powerful anti-aging supplement Niagen, NAD+ may help to reduce, or even reverse premature aging caused by low NAD+ production.1  
 

Today, there are many things that can speed up the natural aging process including exposure to environmental toxins, poor diet, and even lack of exercise.2,3 These factors have been shown in clinical trials to contribute to the premature deterioration of the skin and brain in aging adults. However, there is one more compound that plays a vital role in the aging process known as NAD+. Critical for the proper function of every cell in your body, Nicotinamide Adenine Dinucleotide (NAD+) is involved in regulating the very genes known to accelerate the aging process.4 

As we age, our feelings of energy and overall vitality are linked to this important compound. However, it is common for the aging human body to stop producing the proper amount of NAD+ needed to regulate cellular communication, or energy transfer between cells. For this reason, Vitamin B3 was included in the Niagen formula. This powerful anti-aging supplement includes 250 mg of Nicotinamide Riboside (Vitamin B3) in every capsule of Niagen to help you get more of this essential co-factor for cellular communication. 

NAD+: The Essential Anti-Aging Compound of Niagen 

Nicotinamide Riboside, NAD+’s precursor has recently been studied by a number of scientists for its association with the aging process. Today, many studies can confirm the actions of NAD+ in delivering human anti-aging effects. Here are just 5 of the most notable discoveries: 

1. Cellular Energy. NAD+ is a compound that is involved in energy transfer within each of your cells. Deep inside the energy-producing center called the mitochondria, the process of cellular metabolism relies heavily on the power of NAD+ to transport glucose and fatty acids into cells where it can be converted into energy.5 
 

As NAD+ production tends to decline with age, the communication between your cells can also break down. This breakdown may lead to a dysfunction in the energy-producing center of cells (the mitochondria) and cause a range of physical signs of premature aging.6,7  

However, there is good news for those concerned about their age-related decline of NAD+! Studies have confirmed that boosting levels of NAD+ through supplementation may help to increase the levels of this vital compound inside each cell, thus reducing the risk of cellular dysfunction and reversing the risk of premature aging.8


2. Brain Health. Over time, the depletion of neuronal NAD+ levels may make your brain more susceptible to axonal degeneration (nerve fiber damage) – a common factor of age-related health problems, including stroke and vision loss.9                     

Nicotinamide Riboside, the precursor to potent, and powerful NAD+ inside Niagen, has been shown as an effective way to protect against axonal degeneration.10 


3. Cardiovascular Protection. As an NAD+ precursor, Nicotinamide Riboside has been shown to promote a healthy heart, offering protection to the cardiovascular system.11 One study confirmed the effects of NAD+’s precursors to effectively support the vascular system, both in structure and function, to reduce the risk of age-related heart problems.12 


4. Fat Metabolism. While unwanted weight gain is not necessarily a sign of aging, obesity at any age is one way to increase your risk factors for other illnesses including high blood pressure, diabetes, and even heart disease.13  

Fatty acids are found in many foods. However, if they are left to accumulate inside the body they may cause a range of problems for the cardiovascular system including that of cholesterol buildup.14 One study showed that NAD+ precursors are able to promote a healthy cardiovascular system by offering beneficial effects on cholesterol levels.15  


5. Longevity. Over time, it is normal as part of the aging process for genetic material to become damaged. You see, inside every cell there are long strands of genetic material (DNA) that can become damaged during your life from all types of things like environmental pollutants, as well as harmful UV rays from the sun.16 


However, one recent study on Nicotinamide Riboside has shown that this compound has the ability to actually repair damaged DNA strands.17 This action may help to reduce DNA breakdown and promote longevity.18,19  


Can Niagen Help Me? 

With age, it is common for people to produce much less of the vital anti-aging compound known as NAD+. However, with Niagen, you may gain higher levels of this important compound. And the good news is that clinical trials confirm that supplementation is an effective way to restore youthful NAD+ levels!20 

So, talk to your doctor about the power of Niagen to boost your NAD+ levels. There is no reason NOT to take advantage of this powerful anti-aging supplement today. 

References: 

1. Camacho-Pereira J, Tarragó MG. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016 Jun 14;23(6):1127-1139. 

2. Ruta GancevicieneAikaterini I. Liakou. Skin anti-aging strategies. Dermatoendocrinol. 2012 Jul 1; 4(3): 308–319. 

3. Fernando Gómez-Pinilla. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci. 2008 Jul; 9(7): 568–578. 

4. Imai S, Armstrong CM. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature. 2000;403(6771):795-800. 

5. Sauve AA. NAD+ and vitamin B3: from metabolism to therapies. J Pharmacol Exp Ther. 2008 Mar;324(3):883-93. 

6. Prolla TA, Denu JM. NAD+ deficiency in age-related mitochondrial dysfunction. Cell Metab. 2014;19(2):178-80. 

7. Imai S, Guarente L. NAD+ and sirtuins in aging and disease. Trends Cell Biol. 2014;24(8):464-71. 

8. Garth L. Nicolson, PhD. Mitochondrial Dysfunction and Chronic Disease: Treatment With Natural Supplements. Integr Med (Encinitas). 2014 Aug; 13(4): 35–43. 

9. Jack T. Wang, Zachary A. Medress. Axon degeneration: Molecular mechanisms of a self-destruction pathway. January 9, 2012. 

10. Vaur P, Brugg B. Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration. FASEB J. 2017 Aug 21. 

11. Sebastian C, Satterstrom FK, Haigis MC, et al. From sirtuin biology to human diseases: an update. J Biol Chem. 2012;287(51):42444-52. 

12. Oellerich MF, Potente M. FOXOs and sirtuins in vascular growth, maintenance, and aging. Circ Res. 2012;110(9):1238-51. 

13. Ann Mabe Newman, DSN, APRN, CNE. The Online Journal of Issues in Nursing. Obesity in Older Adults. 

14. Karpe F, Frayn KN. The nicotinic acid receptor--a new mechanism for an old drug. Lancet. 2004 Jun 5;363(9424):1892-4. 

15. Carles CantóRiekelt H. Houtkooper. The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet induced obesity. Cell Metab. 2012 Jun 6; 15(6): 838–847. 

16. Jorge Pinto Soares, António Cortinhas. Aging and DNA damage in humans: a meta-analysis study. Aging (Albany NY). 2014 Jun; 6(6): 432–439. 

17. Jorge Pinto Soares, António Cortinhas. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications 7, Article number: 12948 (2016). 

18. Devita Surjana, Gary M. Halliday. Role of Nicotinamide in DNA Damage, Mutagenesis, and DNA Repair. J Nucleic Acids. 2010; 2010: 157591. 

19. Counter CM. The roles of telomeres and telomerase in cell life span. Mutat Res. 1996 Oct;366(1):45-63. 

20. Samuel A. J. Trammell, Mark S. Schmidt. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nature Communications 7, Article number: 12948 (2016). 

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